Pseudoplate Elevation

As a Blood Collection Needle Factory, let's talk about the problem of false rise in platelets today.

When the blood contains particulate matter similar in size and scattering properties, there is often a false increase in platelet count, such as bacteria, cryoglobulin, cytoplasmic debris, and the like. Blood samples can be reviewed by experienced morphologists for false or reduced platelet counts that can cause serious consequences for specimens that are difficult to interpret or increase in platelets. When the automated blood cell counter method counts platelets, white blood cell debris is mistaken for platelet counting. In the following cases, such as hairy cell leukemia, acute myeloid leukemia, lymphoma or severely infected patients, neutrophil cytoplasmic debris in the blood will increase, ranging in size from 2 to 5 microns, similar to platelets, often as a platelet count.

Blood Collection ACD Tube

Some researchers believe that some white blood cell debris may be related to the formation of cytoplasmic debris by chemotherapy before the patient. Infusion of platelet therapy is required for severely reduced platelet counts in leukemia patients, and false platelet elevation often masks the truth about thrombocytopenia, delaying the need for blood transfusion or treatment. Therefore, it is recommended that in all patients with acute leukemia, if there is an unexplained increase in platelets, it is necessary to perform a microscopic examination of platelets on peripheral blood smears. Pseudo-increased platelet counts may also be associated with other substances, including cryoglobulin, cold fibrinogen, tiny red blood cells, bacteria, Pappenheim's bodies, red blood cell debris, or small spherical red blood cells. Red blood cell debris caused by hemolysis may be smaller than normal platelets, in which case the platelet histogram will have an abnormal peak shape.

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