What Is Tylosin Injection Used for Treating?

Simply put, Tylosin is a natural antibiotic made from bacteria. It works by interfering with the ability of other bacteria to make proteins. It only affects the manufacture of bacterial proteins and therefore does not affect the protein manufacture of mammals, birds or reptiles. Tylosin is a macrolide antibiotic (the same as erythromycin).

How to use this drug?

Tylosin is licensed for use in livestock as a broad-spectrum antibiotic for the treatment of infections, but it has other uses that are not related to its antibiotic activity. In small animals, the antibiotic properties of tylosin are barely used compared to its anti-inflammatory properties in the intestine. Its main use in pets is to treat colitis. In this case, it is not used as an antibiotic to treat the infection, but as an anti-inflammatory to soothe the colon. 

Although there are few formal studies examining this non-antibacterial property of tylosin, it does appear to be effective in this regard and there are many patients whose diarrhea will not improve unless tylosin is given continuously. Tylosin is safe for long-term use and is a good alternative to metronidazole, another intestinal anti-inflammatory/antibiotic that is not suitable for long-term use. 

Tylosin Injection

Tylosin has been used to treat intestinal infections caused by the single-celled parasite Cryptosporidium, as well as intestinal infections caused by the toxin-producing bacterium Clostridium perfringens.

Another common use is to reduce tear staining, especially in white dogs. Small dogs usually have shallow tear wells that cause tears to spill from the face, a condition known as "tear spillage". The subsequent reddish-brown staining of the coat by tear pigmentation is considered unsightly, and tylosin appears to alleviate this condition by an unknown mechanism

Tylosin can also be used in ferrets, rabbits, birds, reptiles and pocket pets.

 Tylosin can be given without food. If a dose is accidentally skipped, do not double the next dose; simply pick it up as usual.

Tylosin Injection Indications

Tylosin Injection is indicated for use in the treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Actinomyces pyogenes; foot rot (necrotic pododermatitis) and calf diphtheria caused by Fusobacterium necrophorum and metritis caused by Actinomyces pyogenes in beef cattle and nonlactating dairy cattle.

In swine, Tylosin Injection is indicated for use in the treatment of swine arthritis caused by Mycoplasma hyosynoviae; swine pneumonia caused by Pasteurella spp.; swine erysipelas caused by Erysipelothrix rhusiopathiae; acute swine dysentery associated with Treponema hyodysenteriae when followed by appropriate medication in the drinking water and/or feed.

Dosage and Administration

For intramuscular injection only.
BEEF CATTLE AND NONLACTATING DAIRY CATTLE - Inject intramuscularly 8 mg per pound of body weight once daily (1 mL of the 200 mg product per 25 pounds). Treatment should be continued 24 hours after symptoms of the disease have stopped, not to exceed 5 days. Do not inject more than 10 mL per site.

SWINE - Inject intramuscularly 4 mg per pound of body weight (1 mL of the 200 mg product per 50 pounds) twice daily. Treatment should be continued 24 hours after symptoms of the disease have stopped, not to exceed 3 days. Do not inject more than 5 mL per site.

The source is from here.